PROTEOME-2 (Part 3)

Molecular biocoding of Prot P62258 14-3-3 protein epsilon, Homo sapiens

BIO INTERVALS – AMINO ACIDS FROM 1 TO 255.

We shall also seek the answers for the following questions: Does the matrix mechanism of biosynthesis of this protein function within the law of the general theory of information and theory of system, and what is the significance of it for understanding of the genetic language of insulin? What is the essence of existence and functioning of this language? Is the genetic information characterized only by biochemical, or also by cyber-information principles?, etc.

Example 1

Number of atoms

M	D	D	R	E	D	L	.	.	E	Q
20	16	16	26	19	16	22	.	.	19	20
1	2	3	4	5	6	7	.	.	15	16

APa-16

M	D	D	R	E	D	L	.	.	E	Q
20	36	52	78	97	113	135	.	.	289	309
1	2	3	4	5	6	7	.	.	15	16

(20+16+16…, + 20) = 309;

APa-16 = 309;

Number of atoms

G	E	E	Q	N	K	E	.	.	N	Q
10	19	19	20	17	24	19	.	.	17	20
239	240	241	242	243	244	245	.	.	254	255

APb-239

G	E	E	Q	N	K	E	.	.	N	Q
309	299	280	261	241	224	200	.	.	37	20
239	240	241	242	243	244	245	.	.	254	255

(20+17…, + 10) = 309;

APb-239 = 309;

Correlation:

APa-16 = APb-239

Example 2

APa-20

M	D	D	R	E	D	.	.	E	R	Y
20	36	52	78	97	113	.	.	341	367	391
1	2	3	4	5	6	.	.	18	19	20

APa-20 = 391;

APb-234

D	M	Q	.	.	V	E	D	E	N	Q
391	375	355	.	.	110	91	72	56	37	20
234	235	236	.	.	250	251	252	253	254	255

APb-234 = 391;

Correlation:

APa-20 = APb-234

Example 3

APa-49

M	D	D	R	E	D	.	.	V	A	Y
20	36	52	78	97	113	.	.	898	911	935
1	2	3	4	5	6	.	.	47	48	49

APa-49 = 935;

APb-206

L	D	T	.	.	V	E	D	E	N	Q
935	913	897	.	.	19	19	16	19	17	20
206	207	208	.	.	250	251	252	253	254	255

APb-206 = 935;

Correlation:

APa-49 = APb-206

Figure 3. Schematic representation of the bio intervals Apa and Apb.

Notes: Aforementioned bio intervals are positioned from number 309, 391, 935, etc. These numbers present the arithmetic progression Apa and APb. The matrix mechanism of protein epsilon in these examples have been analyzed by the application of cybernetic methods, information theory and system theory, respectively. The primary structure of this protein is the exact specification of its atomic composition and the chemical bonds connecting those atoms.

Biological particularity of proteins depends on the order of amino acids in their molecules. Change of that order will lead to the change of their biological particularity. The base parameters that determine the change of status of biosynthesis matrix of macromolecules are the system entropy, volume of information transferred and the level of probability that the genetic information will be transferred as a whole.

System is any group of objects (elements), their relations (number of atoms, atomic number, atomic weight, co-valent radius, molar rotation, electrical negativity, etc...), as well as relations among its attributes. Such is the example of insulin, but also all other proteins. An identical scenario we have in the example of all natural sequences.

The result of the research that we have carried out clearly shows that there is a matrix code in protein. It also shows that the coding system within the amino acidic language gives a full information, not only for the amino acid „record“, but also for its structure, configuration and its various shapes. In the following text we shall discuss the issue of the existence of the insulin code, and also the issue of coding of individual structural levels in this protein.

In those examples there is an exact mathematical balance of groups of aminoacids. This balance is one of important quantitative characteristics of all processes in biochemistry. How functioning of biochemistry is determined through cybernetic information principles, will be discussed further in Table 1.