Language of Proteome Decoded – Part 5

Arithmetic progression of prot P31946 (1433B_HUMAN)

14-3-3 protein beta/alpha

Table 1 Position of amino acids

	1-11	1-27	1-32		1-55	1-80		1- 93	1- 150	1-163	1- 189		1- 213	1-218		1- 232	1- 246
AP	215	499	592		1017	1523		1784	2857	3118	3624		4049	4142		4426	4641
Bio interval	215	284	93		425	506		261	1073	261	506		425	93		284	215
		\	\		I	/		/			\		I	/		/
				1784								1784

Bio interval = (499-215) = 284; (592-499) = 93; (1017-592) = 425; etc.

(215+284+93+525+506+261) = 1784;

Figure 4. Schematic representation of the bio intervals.

Notes: The molecule of protein we can understand as words built from letters, i.e. aminoacids. The meaning of words is determined by positioning of letters. Each of these words has its biochemical base. If this base is expressed by corresponding discrete numbers, we find out that the base has its own program, cybernetic and information characteristics. In fact, we will find out that the sequencing of the molecule is conditioned and determined not only by biochemical, but also by cybernetic and information principles.

Molecular biocoding of 14-3-3 protein beta/alpha

By using the system and information procedures and methods in studying biochemistry, we can analyze the effects of the classical and information parameters in the protein evolution process.

	K	A	T	G	M	Q	A	Q	K	Y	L	S
	24	13	17	10	20	20	13	20	24	24	22	14
	11	27	32	55	80	93	150	163	189	213	218	232
			\			I	I			/
AP-1	215	499	592	1017	1523	1784	2857	3118	3624	4049	4142	4426	>	27846
	I	I	I	I	I	I	I	I	I	I	I	I
Difference	4211	3643	3457	2607	1595	1073	1073	1595	2607	3457	3643	4211		E
	I	I	I	I	I	I	I	I	I	I	I	I
AP-2	4426	4142	4049	3624	3118	2857	1784	1523	1017	592	499	215	>	27846
Sum	4641	4641	4641	4641	4641	4641	4641	4641	4641	4641	4641	4641

27846 = (4641 x Y); Y = 6;

Figure 5. Programmatic and cybernetic algorithm of 14-3-3 protein beta/alpha

Notes: Each peptide chain can have the exact number of aminoacids necessary to meet the strictly determined mathematical conditioning. It can have as many atoms as necessary to meet the mathematical balance of the biochemical phenomenon at certain mathematical level, etc. The digital language of biochemistry has a countless number of codes and analogue codes, as well as other information content. These pictures enable us to realize the very essence of functioning of biochemical processes.

Particularly interesting results we will get when determining numeric values for the information content of atoms and molecules. We will then find out that those values express physical and chemical characteristics of molecules. For example: in a DNA molecule, the polynucleotide chains are connected through an exact cyber-information connections. In those molecules there are also mathematical matrixes of DNA, represented by the number of atoms of four ATCG bases. These matrixes determine the positioning of nucleotides in that molecule. With this, the biological particularities of DNA are determined. Similar mathematical matrixes determine the positioning of nucleotides in the RNA molecule. In the amino acid proteins, they are interconnected into the respective mathematical chains. In those chains are also matrixes where particular mathematical principles apply, the principles that determine the positioning of each amino acid in the chain. Therefore, the herewith discussed research results show that the process of sequencing in bio-macromolecules is conditioned and determined not only through biochemical, but also through cybernetic information principles. The hypothesis here is that the processes in an organism occur only when certain mathematical conditions are met, i.e. when there is a certain mathematical correlation between parameters in those processes. That correlation is expressed by the respective methodology.

We would particularly like to stress here that the genetic, as well as biochemical information in a broader sense of the word, is determined and characterized by very complex cybernetic and information principles. The constantans in those principles are: the number of atoms and molecules, atomic numbers, atomic weight, physical and chemical parameters, even and odd values, codes and analogue codes, standard deviations, frequencies, primary and secondary values, and many other things. The first step toward that discovery was made by the Nobel Prize winner Ehrlich, through his magical ideas that suggest that biochemistry can be observed and studied using a phenomenon out of biochemistry. How functioning of biochemistry is determined through cybernetic information principles, will be discussed further in this text.