Arithmetic progression of prot P31946 (1433B_HUMAN)
14-3-3 protein beta/alpha
Table 1 Position of amino acids
| 1-11 | 1-27 | 1-32 | 1-55 | 1-80 | 1- 93 | 1- 150 | 1-163 | 1- 189 | 1- 213 | 1-218 | 1- 232 | 1- 246 | ||||
AP | 215 | 499 | 592 | 1017 | 1523 | 1784 | 2857 | 3118 | 3624 | 4049 | 4142 | 4426 | 4641 | ||||
Bio interval | 215 | 284 | 93 | 425 | 506 | 261 | 1073 | 261 | 506 | 425 | 93 | 284 | 215 | ||||
| | \ | \ | I | / | / | | | \ | I | / | / | | ||||
| | | | 1784 | | | | | | 1784 | | | | ||||
Bio interval = (499-215) = 284; (592-499) = 93; (1017-592) = 425; etc.
(215+284+93+525+506+261) = 1784;
Figure 4. Schematic representation of the bio intervals.
Notes: The molecule of protein we can understand as words built from letters, i.e. aminoacids. The meaning of words is determined by positioning of letters. Each of these words has its biochemical base. If this base is expressed by corresponding discrete numbers, we find out that the base has its own program, cybernetic and information characteristics. In fact, we will find out that the sequencing of the molecule is conditioned and determined not only by biochemical, but also by cybernetic and information principles.
Molecular biocoding of 14-3-3 protein beta/alpha
By using the system and information procedures and methods in studying biochemistry, we can analyze the effects of the classical and information parameters in the protein evolution process.
| | | | | | | | | | | | | | |
| K | A | T | G | M | Q | A | Q | K | Y | L | S | | |
| 24 | 13 | 17 | 10 | 20 | 20 | 13 | 20 | 24 | 24 | 22 | 14 | | |
| 11 | 27 | 32 | 55 | 80 | 93 | 150 | 163 | 189 | 213 | 218 | 232 | | |
| | | | | | | | | | | | | | |
| | | \ | | | I | I | | | / | | | | |
| | | | | | | | | | | | | | |
AP-1 | 215 | 499 | 592 | 1017 | 1523 | 1784 | 2857 | 3118 | 3624 | 4049 | 4142 | 4426 | > | 27846 |
| I | I | I | I | I | I | I | I | I | I | I | I | | |
Difference | 4211 | 3643 | 3457 | 2607 | 1595 | 1073 | 1073 | 1595 | 2607 | 3457 | 3643 | 4211 | | E |
| I | I | I | I | I | I | I | I | I | I | I | I | | |
AP-2 | 4426 | 4142 | 4049 | 3624 | 3118 | 2857 | 1784 | 1523 | 1017 | 592 | 499 | 215 | > | 27846 |
Sum | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | 4641 | | |
27846 = (4641 x Y); Y = 6;
Figure 5. Programmatic and cybernetic algorithm of 14-3-3 protein beta/alpha
Notes: Each peptide chain can have the exact number of aminoacids necessary to meet the strictly determined mathematical conditioning. It can have as many atoms as necessary to meet the mathematical balance of the biochemical phenomenon at certain mathematical level, etc. The digital language of biochemistry has a countless number of codes and analogue codes, as well as other information content. These pictures enable us to realize the very essence of functioning of biochemical processes.
Particularly interesting results we will get when determining numeric values for the information content of atoms and molecules. We will then find out that those values express physical and chemical characteristics of molecules. For example: in a DNA molecule, the polynucleotide chains are connected through an exact cyber-information connections. In those molecules there are also mathematical matrixes of DNA, represented by the number of atoms of four ATCG bases. These matrixes determine the positioning of nucleotides in that molecule. With this, the biological particularities of DNA are determined. Similar mathematical matrixes determine the positioning of nucleotides in the RNA molecule. In the amino acid proteins, they are interconnected into the respective mathematical chains. In those chains are also matrixes where particular mathematical principles apply, the principles that determine the positioning of each amino acid in the chain. Therefore, the herewith discussed research results show that the process of sequencing in bio-macromolecules is conditioned and determined not only through biochemical, but also through cybernetic information principles. The hypothesis here is that the processes in an organism occur only when certain mathematical conditions are met, i.e. when there is a certain mathematical correlation between parameters in those processes. That correlation is expressed by the respective methodology.
We would particularly like to stress here that the genetic, as well as biochemical information in a broader sense of the word, is determined and characterized by very complex cybernetic and information principles. The constantans in those principles are: the number of atoms and molecules, atomic numbers, atomic weight, physical and chemical parameters, even and odd values, codes and analogue codes, standard deviations, frequencies, primary and secondary values, and many other things. The first step toward that discovery was made by the Nobel Prize winner Ehrlich, through his magical ideas that suggest that biochemistry can be observed and studied using a phenomenon out of biochemistry. How functioning of biochemistry is determined through cybernetic information principles, will be discussed further in this text.
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