Language of Proteome Decoded – Part 4

Arithmetic progression of prot P31946 (1433B_HUMAN)

14-3-3 protein beta/alpha

BIO INTERVALS – AMINO ACIDS FROM 1 TO 246.

We shall also seek the answers for the following questions: Does the matrix mechanism of biosynthesis of this protein function within the law of the general theory of information and theory of system, and what is the significance of it for understanding of the genetic language of insulin? What is the essence of existence and functioning of this language? Is the genetic information characterized only by biochemical, or also by cyber-information principles?, etc.

Example 1

Number of atoms

M	T	M	D	K	S	E	L	V	Q	K
20	17	20	16	24	14	19	22	19	20	24
1	2	3	4	5	6	7	8	9	10	11

AP-1

M	T	M	D	K	S	E	L	V	Q	K
20	37	57	73	97	111	130	152	171	191	215
1	2	3	4	5	6	7	8	9	10	11

(20+17+20…, + 24) = 215;

Number of atoms

E	N	Q	G	D	E	G	D	A	G	E	G	E	N
19	17	20	10	16	19	10	16	13	10	19	10	19	17
233	234	235	236	237	238	239	240	241	242	243	244	245	246

(17+19+10…, + 19) = 215;

AP-2

E	N	Q	G	D	E	G	D	A	G	E	G	E	N
215	196	179	159	149	133	114	104	88	75	65	46	36	17
233	234	235	236	237	238	239	240	241	242	243	244	245	246

Example 2

AP-1

M	T	M	D	K	S	.	.	A	A	A
20	37	57	73	97	111	.	.	473	486	499
1	2	3	4	5	6	.	.	25	26	27

AP-2

I	M	Q	.	.	A	G	E	G	E	N
499	477	457	.	.	88	75	65	46	36	17
219	220	221	.	.	241	242	243	244	245	246

Example 3

AP-1

M	T	M	D	K	S	.	.	A	V	T
20	37	57	73	97	111	.	.	556	575	592
1	2	3	4	5	6	.	.	30	31	32

AP-2

K	D	S	.	.	A	G	E	G	E	N
592	568	552	.	.	88	75	65	46	36	17
214	215	216	.	.	241	242	243	244	245	246

etc.

Biological particularity of proteins depends on the order of amino acids in their molecules. Change of that order will lead to the change of their biological particularity. The base parameters that determine the change of status of biosynthesis matrix of macromolecules are the system entropy, volume of information transferred and the level of probability that the genetic information will be transferred as a whole.

System is any group of objects (elements), their relations (number of atoms, atomic number, atomic weight, co-valent radius, molar rotation, electrical negativity, etc...), as well as relations among its attributes. Such is the example of insulin, but also all other proteins. An identical scenario we have in the example of all natural sequences.

The result of the research that we have carried out clearly shows that there is a matrix code in protein. It also shows that the coding system within the amino acidic language gives a full information, not only for the amino acid „record“, but also for its structure, configuration and its various shapes. In the following text we shall discuss the issue of the existence of the insulin code, and also the issue of coding of individual structural levels in this protein.

In those examples there is an exact mathematical balance of groups of aminoacids. This balance is one of important quantitative characteristics of all processes in biochemistry. How functioning of biochemistry is determined through cybernetic information principles, will be discussed further in Table 1.