ATOMIC GENETIC CODE

ABSTRACT

The modern science mainly treats the biochemical basis of sequencing in bio-macromolecules and processes in biochemistry. One can ask weather the language of biochemistry is the adequate scientific language to explain the phenomenon in that science. Is there maybe some other language, out of biochemistry, that determines how the biochemical processes will function and what the structure and organization of life systems will be? The research results provide some answers to these questions. They reveal to us that the process of sequencing in bio-macromolecules is conditioned and determined not only through biochemical, but also through cybernetic and information principles.

Keywords: Digital Genetics, Genetics Code, RNA Code, Amino acids Code, Evolution

METHODS

The genetic code tables used by the modern science are characterized and determined by principles of biochemistry. However, if in those tables, instead of the UCAG nucleotides we put the number of atoms of those nucleotides, we will get the new tables of the genetic code characterized and determined by programmatic and information principles. Therefore, biochemistry can be explained through a phenomenon out of biochemistry. Particularly interesting results we will get when determining numeric values for the information content of atoms and molecules. We will then find out that those values express physical and chemical characteristics of molecules. For example: in a DNA molecule, the polynucleotide chains are connected through an exact cyber-information connections. In those molecules there are also mathematical matrixes of DNA, represented by the number of atoms of four ATCG bases. These matrixes determine the positioning of nucleotides in that molecule. With this, the biological particularities of DNA are determined. Similar mathematical matrixes determine the positioning of nucleotides in the RNA molecule. In the amino acid proteins, they are interconnected into the respective mathematical chains. In those chains are also matrixes where particular mathematical principles apply, the principles that determine the positioning of each amino acid in the chain.

RESULTS

The herewith discussed research results show that the process of sequencing in bio-macromolecules is conditioned and determined not only through biochemical, but also through cybernetic information principles.

We would particularly like to stress here that the genetic, as well as biochemical information in a broader sense of the word, is determined and characterized by very complex cybernetic and information principles. The constantans in those principles are: the number of atoms and molecules, atomic numbers, atomic weight, physical and chemical parameters, even and odd values, codes and analogue codes, standard deviations, frequencies, primary and secondary values, and many other things. How functioning of biochemistry is determined through cybernetic information principles, will be discussed further in this text.

The Atomic Genetic Code (RNA)

A = 15 atoms; U = 12 atoms; C = 13 atoms; G = 16 atoms;

Number of atoms

UUU=36

Phe=23

UUC=37

Phe=23

CUC=38

Leu=22

UUA=39

Leu=22

UUG=40

Leu=22

CUG=41

Leu=22

CGC=42

Arg=26

GAU=43

Asp=16

GAC=44

Asp=16

CGG=45

Arg=26

AGA=46

Arg=26

AGG=47

Arg=26

GGG=48

Gly=10

UCU=37

Ser=14

UCC=38

Ser=14

AUU=39

Ile=22

AUC=40

Ile=22

UGC=41

Cys=14

AUA=42

Ile=22

AUG=43

Met=20

UGG=44

Trp=27

AAA=45

Lys=24

AAG=46

Lys=24

GGA=47

Gly=10

CUU=37

Leu=22

CCU=38

Pro=17

CCC=39

Pro=17

CUA=40

Leu=22

CCA=41

Pro=17

CCG=42

Pro=17

AAC=43

Asn=17

ACG=44

Thr=17

GGC=45

Gly=10

GAA=46

Glu=19

GAG=47

Glu=19

UAU=39

Tyr=24

GUU=40

Val=19

GUC=41

Val=19

GCC=42

Ala=13

GUA=43

Val=19

GUG=44

Val=19

GCG=45

Ala=13

UCA=40

Ser=14

UCG=41

Ser=14

UAA=42

STOP

AGU=43

Ser=14

AGC=44

Ser=14

ACU=40

Thr=17

ACC=41

Thr=17

AAU=42

Asn=17

ACA=43

Thr=17

GGU=44

Gly=10

UAC=40

Tyr=24

GCU=41

Ala=13

UAG=43

STOP

GCA=44

Ala=13

CAU=40

His=20

CAC=41

His=20

CAA=43

Gln=20

CAG=44

Gln=20

UGU=40

Cys=14

CGU=41

Arg=26

UGA=43

STOP

CGA=44

Arg=26

Number of atoms in triplets UCAG

UUU

UUC

CUC

UUA

UUG

CUG

CGC

GAU

GAC

CGG

AGA

AGG

GGG

UCU

UCC

AUU

AUC

UGC

AUA

AUG

UGG

AAA

AAG

GGA

CUU

CCU

CCC

CUA

CCA

CCG

AAC

ACG

GGC

GAA

GAG

UAU

GUU

GUC

GCC

GUA

GUG

GCG

UCA

UCG

UAA

AGU

AGC

ACU

ACC

AAU

ACA

GGU

UAC

GCU

UAG

GCA

CAU

CAC

CAA

CAG

UGU

CGU

UGA

CGA

.(36+48) = (37+47) = (38+46) = (39+45) = (40+44) = (41+43)

etc.

In fact, we discovered that the mathematical balance in the distribution of codons and amino acids in the genetic code is achieved.

Mathematical position of the nucleotides in codon

The development of prediction methods based on digital theory is focused on the exploration of new digital formulas and algorithms. The genetic code is stored in DNA molecules as sequences of bases: adenine (A) which pairs with thymine (T), and cytosine (C) which pairs with guanine (G), The analog of DNA in a digital genetic algorithm is a number of atoms, atomic numbers, analog codes, etc.

At mathematical evolution of genetic processes, nucleotides TCAG are being transformed to codons UCAG and later to amino acids and various organic composition.

Number of atoms

Second Position of Codon

13,13,15	41	Pro
13,13,13	39	Pro
13,13,15	41	Pro
13,13,16	42	Pro

163

15,16,15	46	Cys
15,16,13	44	Cys
15,16,15	46	Ter
15,16,16	47	Trp

183

15,15,15	45	Tyr
15,15,13	43	Tyr
15,15,15	45	Ter
15,15,16	46	Ter

179

16,15,15	46	Asp
16,15,13	44	Asp
16,15,15	46	Glu
16,15,16	47	Glu

183

708

15,16,15	46	Ser
15,16,13	44	Ser
15,16,15	46	Arg
15,16,16	47	Arg

183

15,15,15	45	Phe
15,15,13	43	Phe
15,15,15	45	Leu
15,15,16	46	Leu

179

15,13,15	43	Ser
15,13,13	41	Ser
15,13,15	43	Ser
15,13,16	44	Ser

171

13,16,15	44	Arg
13,16,13	42	Arg
13,16,15	44	Arg
13,16,16	45	Arg

175

708

15,15,15	45	Ile
15,15,13	43	Ile
15,15,15	45	Ile
15,15,16	46	Met

179

13,15,15	43	Leu
13,15,13	41	Leu
13,15,15	43	Leu
13,15,16	44	Leu

171

16,16,15	47	Gly
16,16,13	45	Gly
16,16,15	47	Gly
16,16,16	48	Gly

187

13,15,15	43	His
13,15,13	41	His
13,15,15	43	Gln
13,15,16	44	Gln

171

708

16,15,15	46	Val
16,15,13	44	Val
16,15,15	46	Val
16,15,16	47	Val

183

1613,15	44	Ala
1613,13	42	Ala
16,13,15	44	Ala
16,13,16	45	Ala

175

15,13,15	43	Thr
15,13,13	41	Thr
15,13,15	43	Thr
15,13,16	44	Thr

171

15,15,15	45	Asn
15,15,13	43	Asn
15,15,15	45	Lys
15,15,16	46	Lys

179

708

Diagonal D1 = 708; Diagonal D2 = 708;

The digital genetic code describe a genotype, which is translated into an organism a phenotype by the processes of cell division.

Mathematical evolution of genetic processes is manifested in different ways. Evolution of groups of atoms is especially interesting. Here are some examples

Digital codon square

A digital codon square of order n is an arrangement of n² numbers, usually distinct integers, in a square, such that the n numbers in all rows, all columns, and both diagonals sum to the same constant. A digital square contains the integers from 1 to n². The term "digital square" is also sometimes used to refer to any of various types of word square.

Number of atoms

163	183	179	183	708
183	179	171	175	708
179	171	187	171	708
183	175	171	179	708
708	708	708	708

D1 = (163+179+187+179) = 708;

D2 = (183+171+171+183) = 708;

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M.

163	183	179	183
183	179	171	175
179	171	187	171
183	175	171	179

(163+183+183+179) = 708;

(179+183+171+175) = 708;

(179+171+183+175) = 708;

187+171+171+179) =708;

163	183	179	183
183	179	171	175
179	171	187	171
183	175	171	179

708

163	183	179	183
183	179	171	175
179	171	187	171
183	175	171	179

708

etc.

Analogue Atomic Genetic Code

How could we adapt the program, ciberfnetic, and informational system to convey more information? Here’s one way. This is an analogue code

“Theoretically the ancient book of DNA could have been analogue. But, for the same reason as for our analogue armada beacons, any ancient book copied and recopied in analogue language would degrade to meaninglessness in very few scribe generations. Fortunately, human writing is digital, at least in the sense we care about here. And the same is true of the DNA books of ancestral wisdom that we carry around inside us. Genes are digital, and in the full sense not shared by nerves”(20).

Correlation of the Code and Analogue Code

The atomic and analogue genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. Specifically, those codes defines a mapping between tri-nucleotide sequences called codons and amino acids; every triplet of nucleotides in a nucleic acid sequence specifies a single amino acid. Because the vast majority of genes are encoded with exactly the same code.

Those codes are universal. The same codons are assigned to the same amino acids and to the same START and STOP signals in the vast majority of genes in animals, plants, and microorganisms.

Analogue Code||Code Code

Example:

Analogue Code of the number 12 is number 21:

21 ||12;

Analogue Code of the number 15 is number 51:

51 ||15;

etc.

At this stage of our research we replaced nucleotides from the Amino Acid Code Matrix with analogue numbers of the atoms in those nucleotides.

A = 15 atoms; T = 15 atoms; C = 13 atoms; G = 16 atoms A = 51; T = 51; C = 31; G = 61;

Analogue codon table

Mathematical position of the nucleotides in codon

Second Position of Codon

31,31,51	113	Pro
31,31,31	93	Pro
31,31,51	113	Pro
31,31,61	123	Pro

442

51,61,51	163	Cys
51,61,31	143	Cys
51,61,51	163	Ter
51,61,61	173	Trp

642

51,51,51	153	Tyr
51,51,31	133	Tyr
51,51,51	153	Ter
51,51,61	163	Ter

602

61,51,51	163	Asp
61,51,31	143	Asp
61,51,51	163	Glu
61,51,61	173	Glu

642

2328

51,61,51	163	Ser
51,61,31	143	Ser
51,61,51	163	Arg
15,16,16	173	Arg

642

51,51,51	153	Phe
51,51,31	133	Phe
51,51,51	153	Leu
51,51,61	163	Leu

602

51,31,51	133	Ser
51,31,31	113	Ser
51,31,51	133	Ser
51,31,61	143	Ser

522

31,61,51	143	Arg
31,61,31	123	Arg
31,61,51	143	Arg
31,61,61	153	Arg

562

2328

51,51,51	153	Ile
51,51,31	133	Ile
51,51,51	153	Ile
51,51,61	163	Met

602

31,51,51	133	Leu
31,51,31	113	Leu
31,51,51	133	Leu
31,51,61	143	Leu

522

61,61,51	173	Gly
61,61,31	153	Gly
61,61,51	173	Gly
61,61,61	183	Gly

682

31,51,51	133	His
31,51,31	113	His
31,51,51	133	Gln
31,51,61	143	Gln

522

2328

61,51,51	163	Val
61,51,31	143	Val
61,51,51	163	Val
61,51,61	173	Val

642

61,31,51	143	Ala
61,31,31	123	Ala
61,31,51	143	Ala
61,31,61	153	Ala

562

51,31,51	133	Thr
51,31,31	113	Thr
51,31,51	133	Thr
51,31,61	143	Thr

522

51,51,51	153	Asn
51,51,31	133	Asn
51,51,51	153	Lys
51,51,61	163	Lys

602

2328

Diagonal D1 = 2328; Diagonal D2 = 2328;

Row 1 = Column 1; Row 2 = Column 2; Row 3 = Column 3; Row 4 = Column 4;

Analogue codon square

A analogue codon square of order n is an arrangement of n² numbers, usually distinct integers, in a square, such that the n numbers in all rows, all columns, and both diagonals sum to the same constant

442	642	602	642	2328
642	602	522	562	2328
602	522	682	522	2328
642	562	522	602	2328
2328	2328	2328	2328

D1 = (442+602+682+602) = 2328;

D2 = (642+522+522+642) = 2328;

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M = 2328;

Correlation:

442	642	602	642
642	602	522	562
602	522	682	522
642	562	522	602

(442+642+642+602) = 2328;

(602+642+522+562) = 2328;

etc.

442	642	602	642
642	602	522	562
602	522	682	522
642	562	522	602

2328

442	642	602	642
642	602	522	562
602	522	682	522
642	562	522	602

2328

Determinsants in Digital analogue Genetic Code

DET (4 x 4)

442	642	602	642
642	602	522	562
602	522	682	522
642	562	522	602

2681856000

2681856000 = (2328 + 2328 + 2328…, + 2328);

There is a mathematical balance within all of the phenomena in the analogue genetic code matrix.

Mathematical correlation of groups of nucleotides are a proof that genetic processes have evolved from one mathematical shape to another one. They are a proof that we can uncover some of hidden secrets in that science, with the help of mathematics.

Atomic numbers

F
i
r
s
t

P
o
s
i
t
i
o
n

58,58,58	174	Phe
58,58,58	174	Phe
58,58,70	186	Leu
58,58,78	194	Leu

728

70,78,58	206	Ser
70,78,58	206	Ser
70,78,70	218	Arg
70,78,78	226	Arg

856

58,70,58	186	Tyr
58,70,58	186	Tyr
58,70,70	198	Ter
58,70,78	206	Ter

776

58,78,58	194	Cys
58,78,58	194	Cys
58,78,70	206	Ter	3168
58,78,78	214	Trp

808

78,70,58	206	Asp
78,70,58	206	Asp
78,70,70	218	Glu
78,70,78	226	Glu

856

58,58,58	174	Ser
58,58,58	174	Ser
58,58,70	186	Ser
58,58,78	194	Ser

728

58,70,58	186	His
58,70,58	186	His
58,70,70	198	Gln
58,70,78	206	Gln

776

58,78,58	194	Arg
58,78,58	194	Arg
58,78,70	206	Arg	3168
58,78,78	214	Arg

808

70,58,58	186	Ile
70,58,58	186	Ile
70,58,70	198	Ile
70,58,78	206	Met

776

70,58,58	186	Thr
70,58,58	186	Thr
70,58,70	198	Thr
70,58,78	206	Thr

776

78,78,58	214	Gly
78,78,58	214	Gly
78,78,70	226	Gly
78,78,78	234	Gly

888

58,58,58	174	Leu
58,58,58	174	Leu
58,58,70	186	Leu	3168
58,58,78	194	Leu

728

78,58,58	194	Val
78,58,58	194	Val
78,58,70	206	Val
78,58,78	214	Val

808

78,58,58	194	Ala
78,58,58	194	Ala
78,58,70	206	Ala
78,58,78	214	Ala

808

58,58,58	174	Pro
58,58,58	174	Pro
58,58,70	186	Pro
58,58,78	194	Pro

728

70,70,58	198	Asn
70,70,58	198	Asn
70,70,70	210	Lys	3168
70,70,78	218	Lys

824

3168

Diagonal D1 = 3168; Diagonal D2 = 3168;

The atomic genetic code describe a genotype, which is translated into an organism a phenotype by the processes of cell division.

Mathematical evolution of genetic processes is manifested in different ways. Evolution of groups of atoms is especially interesting. Here are some examples

Digital codon square

A atomic codon square of order n is an arrangement of n² numbers, usually distinct integers, in a square, such that the n numbers in all rows, all columns, and both diagonals sum to the same constant. A digital square contains the integers from 1 to n². The term "digital square" is also sometimes used to refer to any of various types of word square.

Number of atoms

728	856	776	808	3168
856	728	776	808	3168
776	776	888	728	3168
808	808	728	824	3168
3168	3168	3168	3168

D1 = (728+856+776+808) = 3168; D2 = (808+776+776+808) = 3168;

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M.

728	856	776	808
856	728	776	808
776	776	888	728
808	808	728	824

3168

728	856	776	808
856	728	776	808
776	776	888	728
808	808	728	824

3168

728	856	776	808
856	728	776	808
776	776	888	728
808	808	728	824

3168

etc.

At this stage of our research we replaced nucleotides from the Amino Acid Code Matrix with analogue of the atomic numbers in those nucleotides.

A = 70; U = 58 atoms; G = 78 atoms; C = 58 atoms A = 7; U = 85; G = 87; C = 85;

Analogue codon table

Atomic numbers

F
i
r
s
t

P
o
s
i
t
i
o
n

85,85,85	255	Phe
85,85,85	255	Phe
85,85,07	177	Leu
85,85,87	257	Leu

944

07,87,85	179	Ser
07,87,85	179	Ser
07,87,07	101	Arg
07,87,87	181	Arg

640

85,07,85	177	Tyr
85,07,85	177	Tyr
85,07,07	99	Ter
85,07,87	179	Ter

632

85,87,85	257	Cys
85,87,85	257	Cys
85,87,07	179	Ter	3168
85,87,87	259	Trp

952

87,07,85	179	Asp
87,07,85	179	Asp
87,07,07	101	Glu
87,07,87	181	Glu

640

85,85,85	255	Ser
85,85,85	255	Ser
85,85,07	177	Ser
85,85,87	257	Ser

944

85,07,85	177	His
85,07,85	177	His
85,07,07	99	Gln
85,07,87	179	Gln

632

85,87,85	257	Arg
85,87,85	257	Arg
85,87,07	179	Arg	3168
85,87,87	259	Arg

952

07,85,85	177	Ile
07,85,85	177	Ile
07,85,07	99	Ile
07,85,87	179	Met

632

07,85,85	177	Thr
07,85,85	177	Thr
07,85,07	99	Thr
07,85,87	179	Thr

632

87,87,85	259	Gly
87,87,85	259	Gly
87,87,07	181	Gly
87,87,87	261	Gly

960

85,85,85	255	Leu
85,85,85	255	Leu
85,85,07	177	Leu	3168
85,85,87	257	Leu

944

87,85,85	257	Val
87,85,85	257	Val
87,85,07	179	Val
87,85,87	259	Val

952

87,85,85	257	Ala
87,85,85	257	Ala
87,85,07	179	Ala
87,85,87	259	Ala

952

85,85,85	255	Pro
85,85,85	255	Pro
85,85,07	177	Pro
85,85,87	257	Pro

944

07,07,85	99	Asn
07,07,85	99	Asn
07,07,07	21	Lys	3168
07,07,87	101	Lys

320

3168

Diagonal D1 = 3168; Diagonal D2 = 3168;

Row 1 = Column 1; Row 2 = Column 2; Row 3 = Column 3; Row 4 = Column 4;

Analogue codon square

944	640	632	952	3168
640	944	632	952	3168
632	632	960	944	3168
952	952	944	320	3168
3168	3168	3168	3168

D1 = (944+944+960+320) = 3168;

D2 = (952+632+632+952) = 3168;

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M = 3168;

Correlation:

944	640	632	952
640	944	632	952
632	632	960	944
952	952	944	320

3168

944	640	632	952
640	944	632	952
632	632	960	944
952	952	944	320

3168

944	640	632	952
640	944	632	952
632	632	960	944
952	952	944	320

3168

Determinsants in Digital analogue Genetic Code

DET (4 x 4)

944	640	632	952
640	944	632	952
632	632	960	944
952	952	944	320

197237145600

197237145600 = (3168+ 3168 + 3168…, + 3168);

There is a mathematical balance within all of the phenomena in the analogue genetic code matrix.

Atomic weight

	C	H	N	O	S
A	5	5	5	0	0	15
U	4	4	2	2	0	12
C	4	5	3	1	0	13
G	5	5	5	1	0	16

C = 12,0111; H = 1,00797; N = 14,0067; O = 15,9994; S = 32,064;

A = 135; U = 112; C = 111; G = 151;

The Digital Genetic Code

At the first stage of our research we replaced nucleotides from the Genetic Code with atomic weight of those nucleotides.

Mathematical position of the nucleotides in codon

At mathematical evolution of genetic processes, nucleotides TCAG are being transformed to codons UCAG and later to amino acids and various organic composition.

Second Position of Codon

F
i
r
s
t

P
o
s
i
t
i
o
n

112,111,112	335	Ser
112,111,111	334	Ser
112,111,135	358	Ser
112,111,151	374	Ser

1401

135,151,112	398	Ser
135,151,111	397	Ser
135,151,135	421	Arg
135,151,151	437	Arg

1653

111,135,112	358	His
111,135,111	357	His
111,135,135	381	Gln
111,135,151	397	Gln

1493

112,151,112	375	Cys
112,151,111	374	Cys
112,151,135	398	Ter	6108
112,151,151	414	Trp

1561

151,135,112	398	Asp
151,135,111	397	Asp
151,135,135	421	Glu
151,135,151	437	Glu

1653

111,112,112	335	Leu
111,112,111	334	Leu
111,112,135	358	Leu
111,112,151	374	Leu

1401

135,111,112	359	Thr
135,111,111	358	Thr
135,111,135	382	Thr
135,111,151	398	Thr

1493

151,112,112	375	Val
151,112,111	374	Val
151,112,135	398	Val	6108
151,112,151	414	Val

1561

112,135,112	359	Tyr
112,135,111	358	Tyr
112,135,135	382	Ter
112,135,151	398	Ter

1497

135,112,112	359	Ile
135,112,111	358	Ile
135,112,135	382	Ile
135,112,151	398	Met

1497

151,151,112	414	Gly
151,151,111	413	Gly
151,151,135	437	Gly
151,151,151	453	Gly

1717

111,111,112	334	Pro
111,111,111	333	Pro
111,111,135	357	Pro	6108
111,111,151	373	Pro

1397

111,151,112	374	Arg
111,151,111	373	Arg
111,151,135	397	Arg
111,151,151	413	Arg

1557

151,111,112	374	Ala
151,111,111	373	Ala
151,111,135	397	Ala
151,111,151	413	Ala

1557

112,112,112	336	Phe
112,112,111	335	Phe
112,112,135	359	Leu
112,112,151	375	Leu

1405

135,135,112	382	Asn
135,135,111	381	Asn
135,135,135	405	Lys	6108
135,135,151	421	Lys

1589

6108

Diagonal D1 = 6108; Diagonal D2 = 6108

The atomic genetic code describe a genotype, which is translated into an organism a phenotype by the processes of cell division.

Mathematical evolution of genetic processes is manifested in different ways. Evolution of groups of atoms is especially interesting. Here are some examples

Atomic codon square

Number of atoms

1401	1653	1493	1561	6108
1653	1401	1493	1561	6108
1497	1497	1717	1397	6108
1557	1557	1405	1589	6108
6108	6108	6108	6108

D1 = (1401+1401+1717+1589) = 6108; D2 = (1561+1493+1497+1557) = 6108;

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M.

1401	1653	1493	1561
1653	1401	1493	1561
1497	1497	1717	1397
1557	1557	1405	1589

6108

1401	1653	1493	1561
1653	1401	1493	1561
1497	1497	1717	1397
1557	1557	1405	1589

6108

1401	1653	1493	1561
1653	1401	1493	1561
1497	1497	1717	1397
1557	1557	1405	1589

6108

etc.

At this stage of our research we replaced nucleotides from the Amino Acid Code Matrix with analogue of the atomic weight in those nucleotides.

A = 135; U = 112; C = 111; G = 151;

A = 531; U = 211; C = 111; G = 151;

Analogue codon table

Second Position of Codon

F
i
r
s
t

P
o
s
i
t
i
o
n

211,111,211	533	Ser
211,111,111	433	Ser
211,111,531	853	Ser
211,111,151	473	Ser

2292

531,151,211	0893	Ser
531,151,111	0793	Ser
531,151,531	1213	Arg
531,151,151	0833	Arg

3732

111,531,211	0853	His
111,531,111	0753	His
111,531,531	1173	Gln
111,531,151	0793	Gln

3572

211,151,211	573	Cys
211,151,111	473	Cys
211,151,531	893	Ter	12048
211,151,151	513	Trp

2452

151,531,211	0893	Asp
151,531,111	0793	Asp
151,531,531	1213	Glu
151,531,151	0833	Glu

3732

111,211,211	533	Leu
111,211,111	433	Leu
111,211,531	853	Leu
111,211,151	473	Leu

2292

531,111,211	0853	Thr
531,111,111	0753	Thr
531,111,531	1173	Thr
531,111,151	0793	Thr

3572

151,211,211	573	Val
151,211,111	473	Val
151,211,531	893	Val	12048
151,211,151	513	Val

2452

211,531,211	0953	Tyr
211,531,111	0853	Tyr
211,531,531	1273	Ter
211,531,151	0893	Ter

3972

531,211,211	0953	Ile
531,211,111	0853	Ile
531,211,531	1273	Ile
531,211,151	0893	Met

3972

151,151,211	513	Gly
151,151,111	413	Gly
151,151,531	833	Gly
151,151,151	453	Gly

2212

111,111,211	433	Pro
111,111,111	333	Pro
111,111,531	753	Pro	12048
111,111,151	373	Pro

1892

111,151,211	473	Arg
111,151,111	373	Arg
111,151,531	793	Arg
111,151,151	413	Arg

2052

151,111,211	473	Ala
151,111,111	373	Ala
151,111,531	793	Ala
151,111,151	413	Ala

2052

211,211,211	633	Phe
211,211,111	533	Phe
211,211,531	953	Leu
211,211,151	573	Leu

2692

531,531,211	1273	Asn
531,531,111	1173	Asn
531,531,531	1593	Lys	12048
531,531,151	1213	Lys

5252

12048

Diagonal D1 = 3168; Diagonal D2 = 3168;

Analogue codon square

2292	3732	3572	2452	12048
3732	2292	3572	2452	12048
3972	3972	2212	1892	12048
2052	2052	2692	5252	12048
12048	12048	12048	12048

D1 = 12048; D2 = 12048

The constant sum in every row, column and diagonal is called the magic analogue constant or magic sum, M = 12048;;

Correlation:

2292	3732	3572	2452
3732	2292	3572	2452
3972	3972	2212	1892
2052	2052	2692	5252

12048

2292	3732	3572	2452
3732	2292	3572	2452
3972	3972	2212	1892
2052	2052	2692	5252

12048

2292	3732	3572	2452
3732	2292	3572	2452
3972	3972	2212	1892
2052	2052	2692	5252

12048

etc

Determinsants in Digital analogue Genetic Code

DET (4 x 4)

944	640	632	952
640	944	632	952
632	632	960	944
952	952	944	320

74615095296000

(12048+ 12048 + 12048…, + 12048);

There is a mathematical balance within all of the phenomena in the analogue genetic code matrix.

It is obvious that digital matrix of amino acid code evolved from digital matrix of nucleotide code.

Perspectives

1. About importance of the proposal

Development of science in following period will be based on contemporary digital technology. To conquer new technology it would be far more efficient to use method of reverse engineering for comprehension of phenomen in genetics. We'll give a brief description of that method:

Particularly interesting results we will get when determining numeric values for the information content of atoms and molecules. We will then find out that those values express physical and chemical characteristics of molecules. For example: in a DNA molecule, the polynucleotide chains are connected through an exact cyber-information connections. In those molecules there are also mathematical matrixes of DNA, represented by the number of atoms of four ATCG bases. These matrixes determine the positioning of nucleotides in that molecule. With this, the biological particularities of DNA are determined. Similar mathematical matrixes determine the positioning of nucleotides in the RNA molecule. In the amino acid proteins, they are interconnected into the respective mathematical chains. In those chains are also matrixes where particular mathematical principles apply, the principles that determine the positioning of each amino acid in the chain. Therefore, the herewith discussed research results show that the process of sequencing in bio-macromolecules is conditioned and determined not only through biochemical, but also through cybernetic information principles. The hypothesis here is that the processes in an organism occur only when certain mathematical conditions are met, i.e. when there is a certain mathematical correlation between parameters in those processes. That correlation is expressed by the respective methodology.

2. Where it might be useful

In view of this, our findings might have a series of impacts to the aforementioned work. We are devoted to provide a digital code for each of 20 native amino acids. These digital codes should more complete and better reflect the essence of each of the 20 amino acids. Therefore, it might stimulate a series of future work by using the author’s digital codes to formulate the pseudo amino acid composition for predicting protein structure class, subcellular location, membrane protein type, enzyme family class, GPCR type, protease type, protein-protein interaction, metabolic pathways, protein quaternary structure, and other protein attributes.

We can expect that this discovery will significantly speed up the research of mutational genesis of humans, molecular etymology, in applied biology and genetic engineering, and also it will provide discoveries in new medicines and methods of medicinal treatments.

3. Future steps required

Establish scientific-research project team for development of advanced

technologies in genetics, medicine and biochemistry.

Project team should make concrete program of scientific-research work, where

they should define goals of research, indispensable facilities for implementation of project, project duration, budget, and other conditions.

3. Define rights and duties of all participants in implementation of project.

4. To implement project defined by project documentation.

Research in the field of fundamental sciences

Decode matrix of amino acid code and on the experimental way prove that the matrix really exists. And after that, use that matrix to conquer top technologies in the field of genetics.
Decode matrix of nucleotide code and digital codes which connect that matrix with matrix of amino acid code. And use that matrix to conquer top technologies in the field of biochemistry.
Decode matrix code in Tables of periodic system of chemical elements, and use that matrix to conquer top technologies in the field of chemistry.
Decode matrix code in the nature, and use that matrix to conquer top technologies in the field of all natural sciences.
Decode matrix code of chromosomes in human body.
With the help of above mentioned matrixes, decode map of human DNA.
Decode matrix code of processes in the field of nuclear physics.
Decode insulin matrix code, as well as all other codes from the field of biochemistry.
Other research (Matrix code in Pascal's triangle, Matrix code in astronomy, Matrix code in theoretical physics, determinism, etc.)

4.Paragraph of limitations

1. Confirm that the manuscript has been submitted solely to this journal and is not

published, in press, or submitted elsewhere.

2. Confirm that all the research meets the ethical guidelines, including adherence to

the legal requirements of the study country.

3. Confirm that you have completed and sent a Copyright Transfer Agreement

(CTA) to the Editorial Office.

5.The obtained results

The obtained results are valid. In this manuscript, we proposed the universal genetic code. Mathematics could confirm this fact with 100% scientific accuracy. For example, Table mathematical position of the nucleotides in codon, Digital codon square, Analogue atomic genetic code, Correlation of the code and analogue code Analogue codon table, Analogue codon square, Determinsants in Digital analogue Genetic Code, Determinsants in Digital analogue Genetic Code, Atomic weight Atomic codon square, etc.This mathematic system represents that very universal formula of the genetic code which 100% scientific accuracy. was looking for.

C O N C L U S I O N

It is a rewarding work to translate the biochemical language of amino acids into a digital language because it may be very useful for developing new methods for predicting protein sub cellular localization, membrane protein type, protein structure secondary prediction or any other protein attributes.

This is because ever since the concept of Chou's pseudo amino acid composition was proposed many efforts have been made trying to use various digital numbers to represent the 20 native amino acids in order to better reflect the sequence-order effects through the vehicle of pseudo amino acid composition. Some investigators used complexity measure factor some used the values derived from the cellular automata, some used hydrophobic and/or hydrophilic values, some were through Fourier transform, and some used the physicochemical distance.

Now, it is going to be possible to use the completely new strategy of research in genetics. However, observation of all these relations which are the outcome of the periodic law (actually, of the law of binary coding) is necessary, because it can be of great importance for decoding conformational forms and stereo-chemical and digital structure of proteins.

ATOMIC GENETIC CODE

ponedjeljak, 25. siječnja 2016.

ponedjeljak, 31. kolovoza 2015.

VID 20150629 171519

srijeda, 1. travnja 2015.

The Atomic Genetic Code

The Atomic Genetic Code (RNA)