ponedjeljak, 30. kolovoza 2010.

ATOMIC HEMOGLOBIN CODE(10)



Q6WN29 Hemoglobin subunit beta

Table 20. Bio intervals APa and APb (sequence from 1-147 AA)

M

V

V

K

A

T

Q

C

V

Y

H

20

19

19

24

13

17

20

14

19

24

20

1

34

35

60

63

85

88

113

114

146

147

I

I

I

I

I

I

I

I

I

I

I

APa

20

607

626

1101

1157

1545

1601

2076

2095

2682

2702

I

I

I

I

I

I

I

I

I

I

I

-2682

-2075

-1469

-975

-444

0

444

975

1469

2075

2682

I

I

I

I

I

I

I

I

I

I

I

APb

2702

2682

2095

2076

1601

1545

1157

1101

626

607

20

I

I

I

I

I

I

I

I

I

I

I

M

V

V

Y

V

H

F

L

V

L

H

20

19

19

24

19

20

23

22

19

22

20

1

2

35

36

61

64

86

89

114

115

147

M

V

H

L

T

G

D

E

K

A

A

V

T

A

L

W

G

K

V

N

V

D

E

V

G

G

E

A

L

G

R

L

L

V

V

Y

P

W

T

Q

R

F

F

E

S

F

G

D

L

S

T

P

D

A

V

M

H

N

P

K

V

K

A

H

G

K

K

V

L

G

A

F

S

D

G

L

A

H

L

D

N

L

K

G

T

F

A

Q

L

S

E

L

H

C

D

K

L

H

V

D

P

E

N

F

R

L

L

G

N

V

L

V

C

V

L

A

Q

H

F

G

K

E

F

T

P

Q

V

Q

A

A

Y

Q

K

V

V

A

G

V

A

N

A

L

A

H

K

Y

H

Table 20. Schematic representation of the bio intervals APa and APb (sequence from 1 to 147 AA).

etc.

Notes:Consequently, the periodic law allows for only one form of the amino acid bio interval (Table 1,2,3,n) which can show both the relationships among the amino acids, and their position in peptide chain. As we see, protein code can be developed into the periodic system (and the table), in which each of 20 natural amino acids has an exactly established place.

Biological particularity of proteins depends on the order of amino acids in their molecules. Change of that order will lead to the change of their biological particularity. The base parameters that determine the change of status of biosynthesis matrix of macromolecules are the system entropy, volume of information transferred and the level of probability that the genetic information will be transferred as a whole.

Each peptide chain can have as many atoms as necessary to meet the mathematical balance of the biochemical phenomenon at certain mathematical level. By using the system and information procedures and methods in studying biochemistry, we can analyze the effects of the classical and information parameters in the protein evolution process.

We would particularly like to stress here that the genetic, as well as biochemical information in a broader sense of the word, is determined and characterized by very complex cybernetic and information principles. The constantans in those principles are: the number of atoms and molecules, atomic numbers, atomic weight, physical and chemical parameters, even and odd values, codes and analogue codes, standard deviations, frequencies, primary and secondary values, and many other things.

CONCLUSION

The results of our research show that the processes of sequencing the molecules are conditioned and arranged not only with chemical and biochemical lawfulness, but also with program, cybernetic and informational lawfulness too. At the first stage of our research we replaced nucleotides from the Amino Acid Code Matrix with numbers of the atoms in those nucleotides. Translation of the biochemical language of these amino acids into a digital language may be very useful for developing new methods of predicting protein sub-cellular localization, membrane protein type, protein structure secondary prediction or any other protein attributes. Since the concept of Chou's pseudo amino acid composition was proposed 1,2, there have been many efforts to try to use various digital numbers to represent the 20 native amino acids in order to better reflect the sequence-order effects through the vehicle of pseudo amino acid composition. Some investigators used complexity measure factor 3, some used the values derived from the cellular automata 4-7, some used hydrophobic and/or hydrophilic values 8-16, some were through Fourier transform 17,18, and some used the physicochemical distance 19. It is going to be possible to use a completely new strategy of research in genetics in the future. However, close observation of all these relationships, which are the outcomes of periodic laws (more specifically the law of binary coding), stereo-chemical and digital structure of proteins.